Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality.

ABSTRACT: The transcription factor NF-κB has been associated with a range of pathological conditions of the heart, mainly based on its function as a master regulator of inflammation and pro-survival factor. Here, we addressed the question what effects activation of NF-κB can have during murine heart development. We expressed a constitutively active (CA) mutant of IKK2, the kinase activating canonical NF-κB signaling, specifically in cardiomyocytes under the control of the α-myosin heavy chain promoter. Expression of IKK2-CA resulted in embryonic lethality around E13. Embryos showed defects in compact zone formation and the contractile apparatus, and overall were characterized by widespread inflammation with infiltration of myeloid cells. Gene expression analysis suggested an interferon type I signat

SUBMITTER: Kraut B 

PROVIDER: S-EPMC4634958 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature