Disparities in early death and survival in children, adolescents, and young adults with acute promyelocytic leukemia in California.

ABSTRACT:

Background

Findings from clinical trials and population-based studies have differed with regard to whether mortality within 30 days of diagnosis (early death) of acute promyelocytic leukemia (APL) has decreased in the era of all-trans retinoic acid and anthracycline-based chemotherapy.

Methods

Using data from the California Cancer Registry, the authors investigated 7-day and 30-day mortality and survival in 772 patients who were aged birth to 39 years when they were diagnosed with APL during 1988 to 2011. Logistic regression and Cox proportional models were used to examine the association of early death and survival, respectively, with sociodemographic and clinical factors.

Results

The overall 30-day mortality decreased significantly over time, from 26% (1988-1995) to

SUBMITTER: Abrahao R 

PROVIDER: S-EPMC4635048 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature