How individual participant data meta-analyses have influenced trial design, conduct, and analysis.

ABSTRACT:

Objectives

To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer.

Study design and setting

Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses and knowledge of trials in their respective clinical areas. Experts in the field who did not attend were asked to provide any further examples. We then examined relevant trial protocols, publications, and Web sites to verify the impacts of the IPD meta-analyses. A subgroup of workshop attendees sought further examples and identified other aspects of trial design and conduct that may inf

SUBMITTER: Tierney JF 

PROVIDER: S-EPMC4635379 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature