A comparison of 2 intravenous lipid emulsions: interim analysis of a randomized controlled trial.

ABSTRACT:

Objective

To assess the safety and efficacy of a fish oil-based intravenous fat emulsion (FIFE) in reducing the incidence of cholestasis in neonates compared with the traditional soybean oil-based intravenous fat emulsion (SIFE).

Methods

A double-blind randomized controlled trial was conducted. Nineteen neonates were enrolled (10 SIFE; 9 FIFE). Nutrition assessments and laboratory studies were serially obtained for the duration of PN support or until 6 months' corrected gestational age. Neurodevelopmental outcomes were assessed at 6 and 24 months' corrected age.

Results

There were no differences between groups in demographic characteristics, with an overall median age of 2 days, gestational age of 36 weeks, and birth weight of 2410 g. There were no differences between

SUBMITTER: Nehra D 

PROVIDER: S-EPMC4635445 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature