Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside.

ABSTRACT: Sulforaphane (SFN) is a metabolic by product of cruciferous vegetables and is the biologically active phytochemical found in high concentrations in broccoli. It has been studied extensively for its anticancer efficacy and the underlying mechanisms using cell culture and preclinical models. The immediate precursor of SFN is glucoraphanin, a glucosinolate which requires metabolic conversion to SFN. SFN and other notable isothiocyanates, including phenethyl isothiocyanate and benzyl isothiocyanate found in various cruciferous vegetables, have also been implicated to have a chemopreventive role for breast, colon and prostate cancer. In-vitro and in-vivo anti-cancer activity of this class of compounds summarizing the past two decades of basic science research has previously been r

SUBMITTER: Amjad AI 

PROVIDER: S-EPMC4635516 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature