Intrathecal immunoglobulin A and G antibodies to synapsin in a patient with limbic encephalitis.

ABSTRACT:

Objective

To report on the identification of intrathecally synthesized immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies to synapsin, a synaptic vesicle-associated protein, in a patient with limbic encephalitis.

Methods

Methods included clinical characterization, indirect immunofluorescence, immunoprecipitation, mass spectrometry, immunoblots of wild-type and synapsin I/II/III knockout mice, and cell-based assays with synapsin Ia, Ib, IIa, and IIb plasmids.

Results

A 69-year-old man presented with confusion, disorientation, seizures, and left hippocampal hyperintensities on MRI. CSF examinations revealed an intrathecal IgA and IgG synthesis. Except for IgG antibodies to voltage-gated potassium channels in CSF, screening for known neuronal autoantibodies in

SUBMITTER: Piepgras J 

PROVIDER: S-EPMC4635552 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature