HDAC3 role in medication consumption in medication overuse headache patients: a pilot study.

ABSTRACT:

Background

Medication overuse headache (MOH) is a common and debilitating disorder characterized by generation, perpetuation, and persistence of intense chronic migraine, caused by overuse of analgesics, triptans, or other acute headache compounds. It has been suggested that MOH could share some pathogenetic mechanisms with other kinds of drug addiction. In this regard, histone deacetylases 3 (HDAC3) seems to have a role in the memory processes involved in extinction of drug-seeking behavior in animal models. HDAC3 is inhibited by sodium valproate, a drug with proven efficacy in MOH. Recent evidence suggests an involvement of genetic factors in predisposition to medication overuse.

Results

In this association study, we sequenced all exons, intron/exon junctions, and 3'-5'UTR

SUBMITTER: Pisanu C 

PROVIDER: S-EPMC4635554 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature