Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts.

ABSTRACT:

Study question

What are the effects of fatty acids on placental inflammatory cytokine with respect to toll-like receptor-4/nuclear factor-kappa B (TLR4/NF-kB)?

Summary answer

Exogenous fatty acids induce a pro-inflammatory cytokine response in human placental cells in vitro via activation of TLR4 signaling pathways.

What is known already

The placenta is exposed to changes in circulating maternal fatty acid concentrations throughout pregnancy. Fatty acids are master regulators of innate immune pathways through recruitment of toll-like receptors and activation of cytokine synthesis.

Study design, size, duration

Trophoblast cells isolated from 14 normal term human placentas were incubated with long chain fatty acids (FA) of different carbon length and degree of sa

SUBMITTER: Yang X 

PROVIDER: S-EPMC4635648 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature