Phylogenetic ANOVA: The Expression Variance and Evolution Model for Quantitative Trait Evolution.

ABSTRACT: A number of methods have been developed for modeling the evolution of a quantitative trait on a phylogeny. These methods have received renewed interest in the context of genome-wide studies of gene expression, in which the expression levels of many genes can be modeled as quantitative traits. We here develop a new method for joint analyses of quantitative traits within- and between species, the Expression Variance and Evolution (EVE) model. The model parameterizes the ratio of population to evolutionary expression variance, facilitating a wide variety of analyses, including a test for lineage-specific shifts in expression level, and a phylogenetic ANOVA that can detect genes with increased or decreased ratios of expression divergence to diversity, analogous to the famous Hudson Kreitman Ag

SUBMITTER: Rohlfs RV 

PROVIDER: S-EPMC4635652 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature