Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort.

ABSTRACT: One of the major consequences of the 1986 Chernobyl reactor accident was a dramatic increase in papillary thyroid carcinoma (PTC) incidence, predominantly in patients exposed to the radioiodine fallout at young age. The present study is the first on genomic copy number alterations (CNAs) of PTCs of the Ukrainian-American cohort (UkrAm) generated by array comparative genomic hybridization (aCGH). Unsupervised hierarchical clustering of CNA profiles revealed a significant enrichment of a subgroup of patients with female gender, long latency (>17 years) and negative lymph node status. Further, we identified single CNAs that were significantly associated with latency, gender, radiation dose and BRAF V600E mutation status. Multivariate analysis revealed no interactions but additive effects of p

SUBMITTER: Selmansberger M 

PROVIDER: S-EPMC4635667 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature