Statins in Acute Ischemic Stroke: A Systematic Review.

ABSTRACT:

Background and purpose

Statins have pleiotropic effects of potential neuroprotection. However, because of lack of large randomized clinical trials, current guidelines do not provide specific recommendations on statin initiation in acute ischemic stroke (AIS). The current study aims to systematically review the statin effect in AIS.

Methods

From literature review, we identified articles exploring prestroke and immediate post-stroke statin effect on imaging surrogate markers, initial stroke severity, functional outcome, and short-term mortality in human AIS. We summarized descriptive overview. In addition, for subjects with available data from publications, we conducted meta-analysis to provide pooled estimates.

Results

In total, we identified 70 relevant articles inclu

SUBMITTER: Hong KS 

PROVIDER: S-EPMC4635713 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature