Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development.

ABSTRACT:

Background

Recently, thousands of circular RNAs (circRNAs) have been discovered in various tissues and cell types from human, mouse, fruit fly and nematodes. However, expression of circRNAs across mammalian brain development has never been examined.

Results

Here we profile the expression of circRNA in five brain tissues at up to six time-points during fetal porcine development, constituting the first report of circRNA in the brain development of a large animal. An unbiased analysis reveals a highly complex regulation pattern of thousands of circular RNAs, with a distinct spatio-temporal expression profile. The amount and complexity of circRNA expression was most pronounced in cortex at day 60 of gestation. At this time-point we find 4634 unique circRNAs expressed from 2195 g

SUBMITTER: Veno MT 

PROVIDER: S-EPMC4635978 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature