Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring.

ABSTRACT:

Objective

To utilize a nonhuman primate model to examine the impact of maternal high-fat diet (HFD) consumption and pre-pregnancy obesity on offspring intake of palatable food and to examine whether maternal HFD consumption impaired development of the dopamine system, critical for the regulation of hedonic feeding.

Methods

The impact of exposure to maternal HFD and obesity on offspring consumption of diets of varying composition was assessed after weaning. The influence of maternal HFD consumption on the development of the prefrontal cortex-dopaminergic system at 13 months of age was also examined.

Results

During a preference test, offspring exposed to maternal HFD consumption and obesity displayed increased intake of food high in fat and sugar content relative to off

SUBMITTER: Rivera HM 

PROVIDER: S-EPMC4636015 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature