Ontology highlight
ABSTRACT:
SUBMITTER: Gerlinger M
PROVIDER: S-EPMC4636053 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Nature genetics 20140202 3
Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p ...[more]