Comprehensive transcriptional landscape of aging mouse liver.

ABSTRACT:

Background

Mammalian aging is a highly complex process, a full mechanistic understanding of which is still lacking. One way to help understand the molecular changes underlying aging is through a comprehensive analysis of the transcriptome, the primary determinant of age-related phenotypic diversity. Previous studies have relied on microarray analysis to examine gene expression profiles in different tissues of aging organisms. However, studies have shown microarray-based transcriptional profiling is less accurate and not fully capable of capturing certain intricacies of the global transcriptome.

Methods

Here, using directional whole transcriptome RNA-sequencing of aged mouse liver we have identified a comprehensive high-resolution profile of differentially expressed liver tra

SUBMITTER: White RR 

PROVIDER: S-EPMC4636074 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature