A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli.

ABSTRACT: Hydrogen peroxide (H2O2) is used by phagocytic cells of the innate immune response to kill engulfed bacteria. H2O2 diffuses freely into bacteria, where it can wreak havoc on sensitive biomolecules if it is not rapidly detoxified. Accordingly, bacteria have evolved numerous systems to defend themselves against H2O2, and the importance of these systems to pathogenesis has been substantiated by the many bacteria that require them to establish or sustain infections. The kinetic competition for H2O2 within bacteria is complex, which suggests that quantitative models will improve interpretation and prediction of network behavior. To date, such models have been of limited scope, and this inspired us to construct a quantitative, systems-level model of H2O2 detoxification in Escherichia coli that i

SUBMITTER: Adolfsen KJ 

PROVIDER: S-EPMC4636272 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature