Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.

ABSTRACT: Salt sensitivity, the heterogeneity in the response of blood pressure (BP) to alterations in sodium intake, has been studied extensively, whereas weight sensitivity, the heterogeneity in BP response to weight change, has received scant attention. We examined the relationship of 21 gene polymorphisms previously found to be associated with hypertension, diabetes mellitus, or obesity, with weight sensitivity in the Trial of Nonpharmacologic Interventions in the Elderly, where participants with hypertension were randomized to receive intensive dietary intervention of sodium reduction, weight loss, both, or attention control, whereas pharmacological therapy was kept constant. After correcting for multiplicity, we identified significant associations of 3 polymorphisms with weight sensitivity of

SUBMITTER: Kostis WJ 

PROVIDER: S-EPMC4636329 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature