Pore size is a critical parameter for obtaining sustained protein release from electrochemically synthesized mesoporous silicon microparticles.

ABSTRACT: Mesoporous silicon has become a material of high interest for drug delivery due to its outstanding internal surface area and inherent biodegradability. We have previously reported the preparation of mesoporous silicon microparticles (MS-MPs) synthesized by an advantageous electrochemical method, and showed that due to their inner structure they can adsorb proteins in amounts exceeding the mass of the carrier itself. Protein release from these MS-MPs showed low burst effect and fast delivery kinetics with complete release in a few hours. In this work, we explored if tailoring the size of the inner pores of the particles would retard the protein release process. To address this hypothesis, three new MS-MPs prototypes were prepared by electrochemical synthesis, and the resulting carriers were

SUBMITTER: Pastor EL 

PROVIDER: S-EPMC4636406 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature