Application of flow sensitive gradients for improved measures of metabolism using hyperpolarized (13) c MRI.

ABSTRACT:

Purpose

To develop the use of bipolar gradients to suppress partial-volume and flow-related artifacts from macrovascular, hyperpolarized spins.

Theory and methods

Digital simulations were performed over a range of spatial resolutions and gradient strengths to determine the optimal bipolar gradient strength and duration to suppress flowing spins while minimizing signal loss from static tissue. In vivo experiments were performed to determine the efficacy of this technique to suppress vascular signal in the study of hyperpolarized [1-(13)C]pyruvate renal metabolism.

Results

Digital simulations showed that in the absence of bipolar gradients, partial-volume artifacts from the vasculature were still present, causing underestimation of the apparent reaction rate of pyruvate

SUBMITTER: Gordon JW 

PROVIDER: S-EPMC4636474 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature