High temporal resolution dynamic MRI and arterial input function for assessment of GFR in pediatric subjects.

ABSTRACT:

Purpose

To introduce a respiratory-gated high-spatiotemporal-resolution dynamic-contrast-enhanced MRI technique and a high-temporal-resolution aortic input function (HTR-AIF) estimation method for glomerular filtration rate (GFR) assessment in children.

Methods

A high-spatiotemporal-resolution DCE-MRI method with view-shared reconstruction was modified to incorporate respiratory gating, and an AIF estimation method that uses a fraction of the k-space data from each respiratory period was developed (HTR-AIF). The method was validated using realistic digital phantom simulations and demonstrated on clinical subjects. The GFR estimates using HTR-AIF were compared with estimates obtained by using an AIF derived directly from the view-shared images.

Results

Digital phantom

SUBMITTER: Yoruk U 

PROVIDER: S-EPMC4636486 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature