Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial.

ABSTRACT:

Background

The purpose of the present study was to examine the efficacy of targeting inflammation as a means of improving mood following spinal cord injury (SCI) and explore the potential mechanisms of action.

Methods

The study was a randomized, parallel-group, controlled, clinical trial (NCT02099890) whereby 20 participants with varying levels and severities of SCI were randomized (3:2) to either the treatment group, consisting of a 12-week anti-inflammatory diet, or control group. Outcome measures were assessed at baseline, 1 and 3 months, and consisted of CES-D scores of depression, markers of inflammation as assessed by various pro- and anti-inflammatory cytokines and several amino acids related to depression.

Results

A significant group × time interaction was fou

SUBMITTER: Allison DJ 

PROVIDER: S-EPMC4636770 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature