Network analysis of microRNA and mRNA seasonal dynamics in a highly plastic sensorimotor neural circuit.

ABSTRACT:

Background

Adult neurogenesis and the incorporation of adult-born neurons into functional circuits requires precise spatiotemporal coordination across molecular networks regulating a wide array of processes, including cell proliferation, apoptosis, neurotrophin signaling, and electrical activity. MicroRNAs (miRs) - short, non-coding RNA sequences that alter gene expression by post-transcriptional inhibition or degradation of mRNA sequences - may be involved in the global coordination of such diverse biological processes. To test the hypothesis that miRs related to adult neurogenesis and related cellular processes are functionally regulated in the nuclei of the avian song control circuit, we used microarray analyses to quantify changes in expression of miRs and predicted target mRNA

SUBMITTER: Larson TA 

PROVIDER: S-EPMC4636775 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature