Dissecting the genetic determinants of hemostasis and thrombosis.

ABSTRACT:

Purpose of review

New DNA genotyping and sequencing technologies have facilitated the rapid advancement in our knowledge of human genomic variation and a search for the heritable determinants of complex genetic traits. This review highlights findings from recent genetic studies of complex traits primarily related to venous thromboembolism and provides tools to understand and interpret genome-wide association studies and next-generation sequencing studies.

Recent findings

Genome-wide studies of venous thromboembolic disease and the variation of the protein components of the hemostatic system have been reported. The results of these studies have suggested that variants in a diverse set of known and new genes contribute to the heritability of these traits, but that many of the

SUBMITTER: Desch KC 

PROVIDER: S-EPMC4636909 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature