In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower.

ABSTRACT:

Ethnopharmacological relevance

Nelumbo nucifera Geartn., known as sacred lotus, has been used traditionally in South East Asia as a traditional medicine for various CNS disorders including stress, fever, depression, insomnia, and cognitive conditions.

Aim of the study

To investigate the in vitro cannabinoid and opioid receptor binding affinities, and in vivo behavioral actions of Nelumbo flower extracts and to isolate the potential compounds to treat CNS associated disorders.

Materials and methods

The white and pink flowers of N. nucifera were extracted with 95% EtOH, followed by acid-base partitioning using CHCl3 to give acidic and basic partitions. These partitions were subjected to Centrifugal Preparative TLC (CPTLC) to yield benzyltetrahydroisoquinoline (BTIQ) alk

SUBMITTER: Kumarihamy M 

PROVIDER: S-EPMC4636954 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature