Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines.

ABSTRACT: In therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic research started to investigate the potential benefit of targeting these subtypes in situ. This review will discuss which antigen-presenting cell subtypes are at play and how they have been targeted and finally question the true meaning of targeting antitumor-based vaccines.

SUBMITTER: Goyvaerts C 

PROVIDER: S-EPMC4637118 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature