De-novo collateral formation following acute myocardial infarction: Dependence on CCR2⁺ bone marrow cells.

ABSTRACT: Wide variation exists in the extent (number and diameter) of native pre-existing collaterals in tissues of different strains of mice, with supportive indirect evidence recently appearing for humans. This variation is a major determinant of the wide variation in severity of tissue injury in occlusive vascular disease. Whether such genetic-dependent variation also exists in the heart is unknown because no model exists for study of mouse coronary collaterals. Also owing to methodological limitations, it is not known if ischemia can induce new coronary collaterals to form ("neo-collaterals") versus remodeling of pre-existing ones. The present study sought to develop a model to study coronary collaterals in mice, determine whether neo-collateral formation occurs, and investigate the responsible

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4637183 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature