Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis.

ABSTRACT:

Background

Mobilization of the innate immune response to clear and metabolize necrotic and apoptotic cardiomyocytes is a prerequisite to heart repair after cardiac injury. Suboptimal kinetics of dying myocyte clearance leads to secondary necrosis, and in the case of the heart, increased potential for collateral loss of neighboring non-regenerative myocytes. Despite the importance of myocyte phagocytic clearance during heart repair, surprisingly little is known about its underlying cell and molecular biology.

Objective

To determine if phagocytic receptor MERTK is expressed in human hearts and to elucidate key sequential steps and phagocytosis efficiency of dying adult cardiomyocytes, by macrophages.

Results

In infarcted human hearts, expression profiles of the phagocyt

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4637185 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature