Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification.

ABSTRACT: A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound peptide is then presented on the cell surface where it can be recognized by T helper lymphocytes. NetMHCIIpan is a state-of-the-art method for the quantitative prediction of peptide binding to any human or mouse MHC class II molecule of known sequence. In this paper, we describe an updated version of the method with improved peptide binding register identification. Binding register prediction is concerned with determining the minimal core region of nine residues directly in contact with the MHC binding cleft, a crucial piece of information both for the identification an

SUBMITTER: Andreatta M 

PROVIDER: S-EPMC4637192 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature