Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin.

ABSTRACT:

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One proposed mechanism for the association between social isolation and poor health outcomes is inflammation. Lonely or socially disconnected individuals show greater inflammatory responses, including up-regulation of pro-inflammatory gene expression, and people who are sensitive to cues of social disconnection (e.g., high levels of anxious attachment) exhibit greater inflammation in response to psychological stress. However, no studies have examined how sensitivity to social disconnection may influence pro-inflammatory responses to an inflammatory challenge. In the present study, we investigated the impact of sensitivity to social disconnection (a composite score comprised of loneliness, anxious attachment, fear of negative evaluation, and rejection sensitivity) on pro-

SUBMITTER: Moieni M 

PROVIDER: S-EPMC4637264 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature