High-fructose diet during periadolescent development increases depressive-like behavior and remodels the hypothalamic transcriptome in male rats.

ABSTRACT: Fructose consumption, which promotes insulin resistance, hypertension, and dyslipidemia, has increased by over 25% since the 1970s. In addition to metabolic dysregulation, fructose ingestion stimulates the hypothalamic-pituitary-adrenal (HPA) axis leading to elevations in glucocorticoids. Adolescents are the greatest consumers of fructose, and adolescence is a critical period for maturation of the HPA axis. Repeated consumption of high levels of fructose during adolescence has the potential to promote long-term dysregulation of the stress response. Therefore, we determined the extent to which consumption of a diet high in fructose affected behavior, serum corticosterone, and hypothalamic gene expression using a whole-transcriptomics approach. In addition, we examined the potential of a hig

SUBMITTER: Harrell CS 

PROVIDER: S-EPMC4637272 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature