A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium.

ABSTRACT: The interaction of spiral waves of excitation with atrial anatomy remains unclear. This simulation study isolates the role of atrial anatomical structures on spiral wave spontaneous drift in the human atrium. We implemented realistic and idealised 3D human atria models to investigate the functional impact of anatomical structures on the long-term (∼40 s) behaviour of spiral waves. The drift of a spiral wave was quantified by tracing its tip trajectory, which was correlated to atrial anatomical features. The interaction of spiral waves with the following idealised geometries was investigated: (a) a wedge-like structure with a continuously varying atrial wall thickness; (b) a ridge-like structure with a sudden change in atrial wall thickness; (c) multiple bridge-like structures consisting of

SUBMITTER: Kharche SR 

PROVIDER: S-EPMC4637448 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature