Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population.

ABSTRACT:

Purposes

The present study was designed to investigate the relationship between endoplasmic reticulum amino peptidase 1 (ERAP1) gene polymorphisms and ankylosing spondylitis (AS) in Han population of Shaanxi province.

Methods

100 AS patients and 100 healthy people were enrolled in present study as case and control groups respectively, and the control group was matched with the case group by age and gender. ERAP1 gene rs27434 and rs7711564 polymorphisms were test by TaqMan probe genotyping method. SHEsis software was used to operate linkage disequilibrium (LD) and haplotype analysis between the two single nucleotide polymorphisms (SNPs). χ(2) test was employed to compare the differences of the genotype, allele and haplotype frequencies between the case and control groups. Rel

SUBMITTER: Wang J 

PROVIDER: S-EPMC4637719 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature