Genetic association between CD44 polymorphisms and chronic hepatitis B virus infection in a Chinese Han population.

ABSTRACT:

Aims

This article aimed at discussing the association of chronic hepatitis B virus (HBV) infection with CD44 polymorphisms in Chinese Han population; meanwhile, the interaction of polymorphisms was also analyzed based on chronic HBV infection.

Methods

The genotyping of CD44 polymorphisms was conducted by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 108 HBV infected and 130 healthy persons. The genotype distributions of CD44 rs187115, rs13347 in the control group were checked by Hardy-Weinberg equilibrium (HWE). The strength of the relevance between polymorphism and disease was measured by odds ratio (OR) with corresponding 95% confidence interval (CI) calculated by χ(2) test. The 2×4 crossover analysis method was used to conduct the intera

SUBMITTER: Li F 

PROVIDER: S-EPMC4637725 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature