A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk.

ABSTRACT:

Background

Gout is an inflammatory disease in which genetic factors play a role. ABCG2 is a urate transporter, and the Q141K and Q126X variants of ABCG2 have been associated with a risk of developing gout, though previous studies of these associations have been inconsistent. Therefore, we conducted a meta-analysis to explore the relationship between these genetic variants and gout.

Methods

We examined 8 electronic literature databases. In total, 9 eligible articles on the associations between the Q141K (rs2231142) and Q126X (rs72552713) variants and gout risk, including 11 case-control studies were selected. We used odds ratios (OR) and 95% confidence intervals (CI) to assess the strength of these relationships in dominant, recessive, and co-dominant models.

Results

T

SUBMITTER: Li R 

PROVIDER: S-EPMC4637776 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature