Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice.

ABSTRACT: Chronic uncontrollable stress has been shown to produce various physiological alterations and impair mnemonic functions in the rodent hippocampus. Impacts on neuronal activities, however, have not been well investigated. The present study examined dorsal CA1 place cells to elucidate the computational changes associated with chronic stress effects on cognitive behaviors. After administering chronic restraint stress (CRS; 6 hours/day for ≥21 consecutive days) to adult male mice, several hippocampal characteristics were examined; i.e., spatial learning, in vitro synaptic plasticity, in vivo place cell recording, and western blot analysis to determine protein levels related to learning and memory. Behaviorally, CRS significantly impeded spatial learning but enhanced non-spatial cue learning on

SUBMITTER: Park M 

PROVIDER: S-EPMC4637823 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature