Deciphering Supramolecular Structures with Protein-Protein Interaction Network Modeling.

ABSTRACT: Many biological molecules are assembled into supramolecules that are essential to perform complicated functions in the cell. However, experimental information about the structures of supramolecules is not sufficient at this point. We developed a method of predicting and modeling the structures of supramolecules in a biological network by combining structural data of the Protein Data Bank (PDB) and interaction data in IntAct databases. Templates for binary complexes in IntAct were extracted from PDB. Modeling was attempted by assembling binary complexes with superposed shared subunits. A total of 3,197 models were constructed, and 1,306 (41% of the total) contained at least one subunit absent from experimental structures. The models also suggested 970 (25% of the total) experimentally undet

SUBMITTER: Tsuji T 

PROVIDER: S-EPMC4637837 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature