Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice.

ABSTRACT: Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred mice that captures 90% of the known variation among laboratory mice, to identify the genetic loci controlling rotarod performance and its relationship with body weight in a cohort of 365 mice across 16 CC strains. Body weight and rotarod performance varied widely across CC strains and were significantly negatively correlated. Genetic linkage analysis identified 14 loci that were associated with body weight. However, 45 loci affected rotarod performance, seven of which were also associated with body weight, suggesting a strong link at the geneti

SUBMITTER: Mao JH 

PROVIDER: S-EPMC4637864 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature