MiR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells.

ABSTRACT: MicroRNAs regulate most mammalian genes, and they control numerous aspects of immune system development and function. Their precise roles in the CD8+ T cell response, however, remain unclear. In this report, we show that in the absence of the microRNA miR-150, CD8+ T cells fail to undergo robust expansion and differentiation into short-lived terminal effector cells in response to primary infection with Listeria monocytogenes or Vaccinia virus. Notably, even after transitioning into the memory pool, miR-150(-/-) cells still mount a weaker recall response to secondary infection, and remain less differentiated than their wild-type counterparts. Transcriptome analysis shows miR-150 gene targets are globally upregulated in cells lacking miR-150, and amongst these targets, we found misregulation

SUBMITTER: Smith NL 

PROVIDER: S-EPMC4637875 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature