Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection.

ABSTRACT: The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has secured an important position for their use in bioanalytical assays. Herein, we report a combination of microspheres and microfluidic disk in a unique hybrid platform for highly sensitive and selective detection of dengue virus. Surface engineered polymethacrylate microspheres with carefully designed functional groups facilitate biorecognition in a multitude manner. In order to maximize the utility of the microspheres' specific surface area in biomolecular interaction, the microfluidic disk was equipped with a micromixing system. The mixing mechanism (microballoon mixing) enhances the number of molecular encounters b

SUBMITTER: Hosseini S 

PROVIDER: S-EPMC4637926 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature