Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring.

ABSTRACT: Maternal food intake has a significant effect on the fetal environment, and an inadequate maternal diet may result in intrauterine growth restriction. Intrauterine growth restriction newborn rat pups nursed by normal diet-fed dams exhibited rapid catch-up growth, which plays a critical role in the risk for metabolic and cardiovascular disease in later life. Specifically, one-carbon metabolism in the liver plays a critical role in placental and fetal growth. Impaired functioning of one-carbon metabolism is associated with increased homocysteine levels. In this study, we applied a comprehensive proteomic approach to identify differential expression of proteins related to one-carbon metabolism in the livers of rat offspring as an effect of maternal food restriction during gestation. Data are

SUBMITTER: You YA 

PROVIDER: S-EPMC4638034 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature