Reconstruction of 3D genome architecture via a two-stage algorithm.

ABSTRACT:

Background

The three-dimensional (3D) configuration of chromosomes within the eukaryote nucleus is an important factor for several cellular functions, including gene expression regulation, and has also been linked with cancer-causing translocation events. While visualization of such architecture remains limited to low resolutions, the ability to infer structures at increasing resolutions has been enabled by recently-devised chromosome conformation capture techniques. In particular, when coupled with next generation sequencing, such methods yield an inventory of genome-wide chromatin contacts or interactions. Various algorithms have been advanced to operate on such contact data to produce reconstructed 3D configurations. Studies have shown that these reconstructions can provide adde

SUBMITTER: Segal MR 

PROVIDER: S-EPMC4638111 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature