Changes in peripheral blood immune cell composition in osteoarthritis.

ABSTRACT:

Objectives

Immune age-related abnormalities may synergise with osteoarthritis (OA) pathology. We explored whether abnormalities in the blood immune cell composition are present in OA, beyond defects typically associated with ageing.

Design

Blood was collected from 121 healthy controls (HC) and 114 OA patients. Synovial biopsies were obtained from another 52 OA patients. Flow cytometry was used to establish the frequencies of lineage subsets, naïve, memory and regulatory T and B-cells, cells with an abnormal phenotype related to inflammation (IRC) and memory-like CD8(+) T-cells. Multivariate analysis of covariance (MANCOVA) was used to determine whether the relative subset frequencies differed between HC and OA, controlling for age.

Results

Expected histology and T/B-c

SUBMITTER: Ponchel F 

PROVIDER: S-EPMC4638189 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature