Isoniazid Prophylactic Therapy for the Prevention of Tuberculosis in HIV Infected Adults: A Systematic Review and Meta-Analysis of Randomized Trials.

ABSTRACT:

Background

Infection with Human Immunodeficiency virus (HIV) is an important risk factor for Tuberculosis (TB). Anti-Retroviral Therapy (ART) has improved the prognosis of HIV and reduced the risk of TB infected patients. Isoniazid Preventive Therapy (IPT) aims to reduce the development of active TB in patients with latent TB.

Objective

Systematically review and synthesize effect estimates of IPT for TB prevention in adult HIV patients. Secondary objectives were to assess the effect of IPT on HIV disease progression, all-cause mortality and adverse drug reaction (ADR).

Search strategy

Electronic databases were searched to identify relevant articles in English available by September 11th 2015.

Selection criteria

Research articles comparing IPT to placebo or no t

SUBMITTER: Ayele HT 

PROVIDER: S-EPMC4638336 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature