Genome-wide significant linkage of schizophrenia-related neuroanatomical trait to 12q24.

ABSTRACT: The insula and medial prefrontal cortex (mPFC) share functional, histological, transcriptional, and developmental characteristics, and they serve higher cognitive functions of theoretical relevance to schizophrenia and related disorders. Meta-analyses and multivariate analysis of structural magnetic resonance imaging (MRI) scans indicate that gray matter density and volume reductions in schizophrenia are the most consistent and pronounced in a network primarily composed of the insula and mPFC. We used source-based morphometry, a multivariate technique optimized for structural MRI, in a large sample of randomly ascertained pedigrees (N = 887) to derive an insula-mPFC component and to investigate its genetic determinants. Firstly, we replicated the insula-mPFC gray matter component as an ind

SUBMITTER: Sprooten E 

PROVIDER: S-EPMC4639444 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature