Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.

ABSTRACT: The epithelial to mesenchymal transition (EMT) is an essential process that occurs repeatedly during embryogenesis whereby stably adherent cells convert to an actively migrating state. While much is known about the factors and events that initiate the EMT, the steps that cells undergo to become directionally migratory are far less well understood. Zebrafish embryos lacking the transcription factors Tbx16/Spadetail and Mesogenin1 (Msgn1) are a valuable system for investigating the EMT. Mesodermal cells in these embryos are unable to perform the EMT necessary to leave the most posterior end of the body (the tailbud) and join the pre-somitic mesoderm, a process that is conserved in all vertebrates. It has previously been very difficult to study this EMT in vertebrates because of the multiple

SUBMITTER: Manning AJ 

PROVIDER: S-EPMC4639448 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature