Basal Lamina Mimetic Nanofibrous Peptide Networks for Skeletal Myogenesis.

ABSTRACT: Extracellular matrix (ECM) is crucial for the coordination and regulation of cell adhesion, recruitment, differentiation and death. Therefore, equilibrium between cell-cell and cell-matrix interactions and matrix-associated signals are important for the normal functioning of cells, as well as for regeneration. In this work, we describe importance of adhesive signals for myoblast cells' growth and differentiation by generating a novel ECM mimetic peptide nanofiber scaffold system. We show that not only structure but also composition of bioactive signals are important for cell adhesion, growth and differentiation by mimicking the compositional and structural properties of native skeletal muscle basal lamina. We conjugated laminin-derived integrin binding peptide sequence, "IKVAV", and fibron

SUBMITTER: Yasa IC 

PROVIDER: S-EPMC4639731 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature