Reversed reactivity of anilines with alkynes in the rhodium-catalysed C-H activation/carbonylation tandem.

ABSTRACT: Development of multicatalytic approach consisting of two or more mechanistically distinct catalytic steps using a single-site catalyst for rapid and straightforward access of structurally complex molecules under eco-benign conditions has significance in contemporary science. We have developed herein a rhodium-catalysed C-H activation strategy which uses an unprotected anilines and an electron-deficient alkynes to C-C bonded products as a potential intermediate in contrast to the archetypical C-N bonded products with high levels of regioselectivity. This is followed by carbonylation of C-H bond activated intermediate and subsequent annulation into quinolines has been described. This rhodium-catalysed auto-tandem reaction operates under mild, environmentally benign conditions using water as

SUBMITTER: Midya SP 

PROVIDER: S-EPMC4639815 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature