Convergence of methods for coupling of microscopic and mesoscopic reaction-diffusion simulations.

ABSTRACT: In this paper, three multiscale methods for coupling of mesoscopic (compartment-based) and microscopic (molecular-based) stochastic reaction-diffusion simulations are investigated. Two of the three methods that will be discussed in detail have been previously reported in the literature; the two-regime method (TRM) and the compartment-placement method (CPM). The third method that is introduced and analysed in this paper is called the ghost cell method (GCM), since it works by constructing a "ghost cell" in which molecules can disappear and jump into the compartment-based simulation. Presented is a comparison of sources of error. The convergent properties of this error are studied as the time step Δt (for updating the molecular-based part of the model) approaches zero. It is found tha

SUBMITTER: Flegga MB 

PROVIDER: S-EPMC4639942 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature