Prospects for therapeutic tolerance in humans.

ABSTRACT:

Purpose of review

To provide an overview of recent advances and future possibilities for therapeutic tolerance.

Recent findings

Allograft survival despite complete immunosuppressant withdrawal has been demonstrated in selected renal-transplant recipients with haematopoietic chimerism. Early clinical trials of mesenchymal stromal cell therapy have shown promising results in several autoimmune diseases. Regulatory T cells show potential benefit in graft versus host disease, although challenges to ex-vivo expansion remain. Targeted modulation of T-cell function in vivo with monoclonal antibodies has shown beneficial effects in phase II/III trials of multiple sclerosis (alemtuzumab) and type I diabetes mellitus (teplizumab, otelixizumab). Emerging data from animal models suggest

SUBMITTER: Baker KF 

PROVIDER: S-EPMC4640179 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature