Multivariate dynamic prediction of ischemic infarction and tissue salvage as a function of time and degree of recanalization.

ABSTRACT: Benefit of endovascular recanalization beyond established treatment time windows likely exists in select stroke patients. However, there is currently no imaging model that predicts infarction adjusting for elapsed time between the pathologic snapshot of admission imaging until endovascular recanalization. We trained and cross validated a multivariate generalized linear model (GLM) that uses computer tomography perfusion and clinical data to quantify patient-specific dynamic change of tissue infarction depending on degree and time of recanalization. Multicenter data of 161 patients with proximal anterior circulation occlusion undergoing endovascular therapy were included. Multivariate voxelwise infarct probability was calculated within the GLM. The effect of increasing time to treatment and

SUBMITTER: Kemmling A 

PROVIDER: S-EPMC4640330 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature